100 thoughts on “Quyen Nguyen: Color-coded surgery

  1. I heard Roger Tsien give this talk. He makes it sound way more cooler, but I guess his talk is geared towards scientists.

  2. I didn't even watch this video, but much thanks for changing the screenshot thumbnail from the picture that looked like a colored vagina.

  3. so in other words big pharmaceutical companies are stopping this since there is less money in it because less people will need to take pills for an extended period of time?

  4. Not my favorite speaker. She has a very long introduction, which is barely to the point, and then describes a technology which sounds as if it had been developed by someone else (Roger Tsien?). Oh, wait, now I get why she blabbers about medicine being a team work…

  5. @HKragh Because the tracking is not as specific as she makes it sound. It's still easier to just cut it out, once you have a ball park estimate of what its limits are.

  6. If I were to give a TED talk I would be much less offended by the fact that the intro is slightly loud than I would be by all of the people obsessing about it instead of typing serious comments that pertain to the talk.

  7. take it to Canada, England, France…places with Universal healthcare, they actually care about their people. we need CHANGE!!!!!!

  8. Interesting. I did an internship at a company working on fluorescense imaging. They actually do the same thing they are here, but for biological research. Good to see technology from different fields leaking other into others in a good way.

  9. Now if we can only develop code to inject into the presentation that highlights the redundant (cancerous) parts of the talk and leaves us with the most interesting, remaining bits (the images and videos) behind.

  10. No sucessful inovation starts with one man rising above is calluges and being sucessful but the parisite say its not fare and so he loses hope

  11. This is so fucking cool they should put this into every damn hospital asap holy shit this is awesome. this will change surgery.

  12. I think breakthroughs like this are really great, but not to be taken as hope for a cure. Cancer occurs as a result of our body not being able to rid mutated cells from our body. Every single day our body disposes of mutated cells that have the potential to become cancer. The question should not be: how do we cut it out effectively?, but 'what makes this system fail and how do we prevent its failure?' We cannot smoke, drink, eat junk and prey that modern medicine will save us when we get sick…

  13. @molapft You have no idea about all the possible causes of cancer, do you? Unfortunately, going through life only eating nuts and berries won't keep you from getting cancer. Sure, eating healthy is important, but to say our diet is the 'only' cause of cancer is naive and misinformed!

  14. Transcript:15:18 I'd like to leave you this final thought, successful innovation is not a single break through, it is not a sprint, it is not an event for the solo runner, successful innovation is a team sport of a relay race, it requires one team to break through, another team to get that accepted and adopted, and this takes long term steady courages of day-in and day-out struggle to educate, to persuade and to win acceptance, that is the light that I would shine on health medicine today.

  15. @adolthitler There are some radiation therapies that are injected and target cancerous cells, notably thyroid cancer with Iodine-131. In the case of solid tumors, it might simply be faster to remove them surgically. Or, there may be trouble finding a toxin that only begins killing tissue where it "lands" (in the cancer cell), rather than everything it touches on its way through the bloodstream. But I bet they're working on it.

  16. @adolthitler A coworker went to Dr. Tsien's talk and told me about this. Attaching a toxin instead of GFP/dye to the polycation-cleavable-polyanion complex is already being studied. The problem is the liver, like tumors, also produces many of the enzymes that can cleave. So the toxins will accumulate in the liver, which would be bad.

  17. @HKragh A coworker went to Dr. Tsien's talk and told me about this. The problem is the liver, like tumors, also produces many of the enzymes that can cleave. So the poison/toxin will accumulate in the liver, which would be bad.

  18. her voice sounds like its gonna break sometimes which is quite annoying tbh, but good discovery nontheless.

  19. How about realtime mri or cat scans for better visualisation techniques for surgeons to see operatable regions better or maybe realtime higher quality colour 3d ultrasounds as well as colour microscopes improving better instrumentation and visual systems.

  20. i am going to work in cornell as research assistant on same concept..in surgical oncology ..awesome..
    nicely explained..

  21. being in my surgery rotation now I envy next generations as i see the future of surgery that 5 years later our fellows will not have to memories anatomical variation of body structures :@ :@ 😀

  22. Hope in the near future this technology can tag somenew color materias to our contrast medium, so we radiologist can point out what happen in the body before surgery. LYC (TW)

  23. This is amazing! It is obvious that technology will produce better results in excising tumors and minimize inadvertent injuries in the OR. It's a shame that funding for such endeavors may be difficult, since drugs for one-time use are less likely to be developed. With the appropriate funding anything is possible however.

  24. this is outstanding; i love it. way to go. as a pathologist, i know what is that mean. great for medicine…so called "best medicine"…

  25. 1. Would it be possible to use recombinant DNA to modify white blood cells via in vitro to be directed to the florescence? For example: use a wet lab to modify CD8 to be directed to the florescence molecule for possible destruction.

    2. Once the fluoresces molecule is cleaved at contact with desired tissue. Could the anion portion of the tracer be tagged in use to activate a drug which is free floating in the cytoplasm? This way the drug is only activated at the site desired.

  26. Brilliant, a huge step forward, if a particular agent can produce color in an specfic malignant tissue, is just a matter of time to get such agent combined with a drug that destroys the tumor and nothing else.

  27. ( سنريهم آياتنا في الآفاق وفي أنفسهم حتى يتبين لهم أنه الحق أولم يكف بربك أنه على كل شيء شهيد ( 53 ) ) [ ص: 493 ]

  28. I wonder if a marker could be placed on plaques in vascular disease marking occlusions so a surgeon could easier bypass the blocked spots….????

    Es título resume la charla de esta cirujana:
    Esta versión permite colocar subtítulos en español muy fácilmente.
    Con frecuencia en las cirugías RADICALES cortan más de lo que debería con gran perjuicio de los pacientes, razón por la que este video de Quyen Nguyen, utilizando un invento de (marcador molecular) ROGER CHEN, premio nobel de química https://es.wikipedia.org/wiki/Roger_Y._Tsien que le permite al cirujano en su procedimiento diferenciar (como en las láminas de anatomía), nervios, ganglios, músculos, arterias, venas y los bordes de los tumores a sacar ( total o en qué porcentaje); por ejemplo en una cirugía de próstata la mayoría de los nervios no se ven y el médico se guía no por lo que ve sino por sus conocimientos anatómicos, es decir donde deberían estar los nervios, por eso esta cirujana dice que !ES UNA LOCURA OPERAR EN ESTAS CONDICIONES¡; "tratamos de extirpar el cáncer y no sabemos dónde está y tratamos de preservar nervios y tampoco sabemos donde estan".
    Quyen Nguyen apoyada por un premio nobel, ilustra la verdadera realidad de los quirófanos y fuente de tantos errores.
    Lo contado sobre el ganglio centinela es genial, permite saber si hay mas afectación cancerigena o cuando para decidir cuanto intervenir con la cirugía.

  30. How could ANY DR say that they are NOT interested in funding and pursuing this technology for their patients?! This is GROUNDBREAKING! 🙂

  31. This is brilliant. But I 'm just curious about the specificity of the labeling approach, for which not only tumor tissues make proteases, some other cells produce protease as well. So there could be other activitable probes that only emit fluorescence in particular types of tumors.

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