61 thoughts on “Parkinson’s Disease | Clinical Presentation | Part 1

  1. I saw that in some videos you can use subtitles. Why in other like this is not possible? Meanwhile, Thank you very much for your efforts

  2. When you say the AP is more intense, I thought they were always the same magnitude it's the frequency that effects intensity so does dopamine binding to D1 increase frequency?

  3. I was a cardiac nurse but left the profession for twelve years and I am taking a refresher course to regain my license! Unfortunately just reading textbook doesn't work, thank you so very much for your help in getting another nurse, me!, back to what I love..my patients and caring for them! I am blown away by your videos! Again can't say enough, ty ty THANK YOU! I am recommending you to my course director!

  4. Your explanation was the best, and I've seen Khanacadamy and other big names where they used a chart-like explanation. Yours was exceptional. Thank you!

  5. Bestest lecture For the students. One an only video from where I acquire the knowledge on parkinson's disease. Great job thank you sir

    I can't understand all of your words in one time .
    edit : I love your clips and channel anyway.

  7. Great video! Your pronunciation of some of the terms ( putamen, globus pallidus, synapse, etc. ) is unconventional which may be a little confusing for those of us who are used to the conventional pronunciation, but other than that, your explanations are great. Keep up the good work!

  8. UPATE: direct and indirect pathways are being removed from the teaching of the basal ganglia due to newer research!!!

  9. This video was exceptional! Thank you very much! Can you please do a video for multiple sclerosis like the ones for PD? It would really help…thank you!!

  10. Just remember..stimulation of direct pathway cause stimulation of cortex..while stimulation of indirect causes inhibition of the cortex

  11. I literally want to cry from happiness because YOU HAVE EXPLAINED IT ABSOLUTELY BRILLIANTLY and I am so glad I understand it now! THANK YOU THANK YOU THANK YOU

  12. Perfect summary! maybe rename this video to Basal Ganglion overview or something because it took me forever to come across this gold! Thanks for This vid!

  13. Perfect explanation. Thank you so much.
    Could you please make up a video on the pathopgysiology of restless leg syndrome and why dopaminergic drugs work for it? Thank you.

  14. Very beautifully and clearly explained presentation! Thank you for making me understand better! Thank you so much from Malaysia 🇲🇾 4/8/2019

  15. You said direct pathway stimulates agonist and indirect pathway inhibits antagonist. Dopamine by it's action stimulates direct pathway inturn stimulating and intensifying agonist and inhibits indirect pathway and inturn antagonist are stimulated. Isn't it? Then what is the use of activating both agonist and antagonist simultaneously

  16. The continuation of previous question : Dopamine stimulates both agonist and antagonist at the same time. I.e movements are offset.
    Kindly fine-tune this doubt.

  17. 👍🏼👍🏼 I am a Pk patient . 🤔Too much info for my brain to process and retain 🤯🗣But your presentation is amazing 👏🏽👏🏽and also good source of reference that I will frequently go back to👏🏽. 👍🏼👍🏼👍🏼🙏🙏🙏🙏

  18. Summary

    Cortex (glu) + SubNigra (D1)→ ↑striatum (↑Gaba) → ↓globus pallidus internus (↓Gaba) → ↑thalamus → ↑motor cortex

    Note how the increase in gaba at the first step decreases gaba at the second step, effectively cancelling each other out.

    Indirect pathways:
    Cortex (glu) + SubNigra (D2)→ ↑striatum (↑Gaba) → ↓globus pallidus externus (↓Gaba) → ↑subthalamus (↑glu)→ ↑globus pallidus internus (↑Gaba) → ↓thalamus → ↓motor cortex

  19. I'm so thankful for this research!! How do you erase the past of all the people that rejected you and treated you like dirt out of sheer ignorance?

  20. The new audiobook on Parkinson's Disease written from an informed patient's perspective and filled with great complementary therapies has just been released for sale! #Parkinsons #PD #ParkinsonsDisease

  21. Not Just Parkinson's Most the Neurodegenerative disease can be controlled through Ayurveda Treatment

    I have been to VIAMS, an Ayurveda Hospital in Kerala, India

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