LIFESPAN Book by David Sinclair: Aging & Aging-Related Diseases


by one more time I this week it could
started a review of the book LIFESPAN by David Sinclair it’s been an
interesting and you know even having to repeat it three times because again our
technical problems it’s been an interesting and fun book for me to read
because he covers items that I’ve covered in multiple videos in the past
so when I’m gonna end up doing a series on the review of this book LIFESPAN he’s
got a lot David Sinclair has gotten a lot of interest recently because he I
think a lot of it because he appeared on Joe Rogan got a who’s got a huge
viewership he wrote this book and sure enough he’s got he’s got a lot of
interest boiling up around him one of the first items that he talks about is
whack-a-mole medicine that’s the first time I’ve seen that term used and it’s
very very accurate it’s a major focus point for me have you ever noticed that
people tend to stay healthy until their 40s then they get sicker and sicker and
sicker that’s what we’re talking about here and in fact if you look at
gerontologists people that study aging they’ll point out charts like this chart
that was in the book LIFESPAN here’s the point to this you can wipe out death
from cancer heart attack diabetes lung disease dementia heart failure but look
at the other lines on this graph you can knock out one of them but the others
will get you and if you look at medicine that’s one of the problems one of my
major concerns with medicine we’re organized by organ system so for example
docs go to school another two or three or four years to learn about the
heart and become cardiologist or to learn about the brain
to become a neurologist or learn about kidneys to become a nephrologist we
target a specific disease or organ and we try to delay that a specific targeted
disease but that’s all wrong we need diseases don’t start in our 40s
in a specific organ system they start far far earlier and they start on a
molecular and cellular level so it’s not until we began to focus on molecular and
cellular processes are we actually going to start making a difference in terms of
lifespan again age itself is the strongest risk factor
for these age-related diseases that’s why they call them age-related diseases
now he goes on to talk about hallmarks of aging we’ve all heard him you’ve if
you’ve seen my videos very much you’ve heard me mention things like telomere
attrition mitochondrial dysfunction and mitochondrial dysfunction has been the
major and reigning theory behind aging for many for decades first came out in
the 50s and 60s where there was a focus on the mitochondria is where we burned
we use oxygen to burn and there’s a lot it’s like a furnace and there’s a lot of
spillover and oxidation of products oxygen oxidation and so therefore you’ve
had this major focus on antioxidants for how many decades and no matter how many
antioxidants we take we’re still having heart attacks strokes blindness dementia
you name it cellular senescence this is a big deal
especially in terms of fat if you remember my recent video on the secret
life of fat cells fat cells in and of themselves
are more of a they’re not just storage they create hormones then there’s a
thing called zombie cells cells that have are dying but they don’t quite die
just yet these cells generate incredible inflammatory markers
inflammatory metabolism when we’ve talked about epigenetic alterations
epigenetics the methylone it’s where there’s so many of our genes that have
become methylated it’s where we get insulin resistance it’s not that our
genes have changed from our 20s when we were healthy to the time that were 60s
and getting insulin resistant it’s that we can’t access those genes anymore
that’s what metformin is about that’s what fasting is about that’s what some
of these these focus points are on anti-aging now he talked to and did a
lot of his early research on a yeast cell the yeast cell Saccharomyces
cerevisiae I don’t worry about that clinical name but as you see down at the
bottom you get these loop after loop after loop of extra DNA in fact that
lead leads to that’s what led to his theory of aging it’s because of the
informational theory of aging he he tells a story and and uses the analogy
imagine that you go to a classical concert or a jazz guy and sir
it’s a fellow pianist and everything’s going well except you
here a couple of extra notes they just weren’t supposed to be there it’s quick
and easy to forget about him but then just a few seconds later you get more
and then more and then pretty soon it has ruined the music extra notes now
what is he talking about he’s talking about the DNA and he describes a process
there’s a thing called Werner syndrome it’s
disease where it’s a genetic disease where people cannot repack their DNA
appropriately so what happens is when they unpack a specific gene they don’t
repack it and it just starts coming out and more and more loops the he described
the process is looking like tight yarn that came tightly wound in a bag but
then a cat or something clawed holes in the plastic bag and then you get loop
after loop after loop of DNA coming out these Werner syndrome patients by the
way look fine under age ten but once they start getting 20 they look like
they’re 50 or 60 and they typically die in their 40s so it’s a process where
aging is just going way too quickly the first few minutes on my silent one
of my silent presentations we were talking about metformin and DNA this is
Nir Barzilai the principle investigator of metformin of the metformin trial came
we’ll talk about that later in one of the other videos this is a picture of
David Sinclair and for those of you who hate the idea of caloric restriction
caloric restriction still is effective Roy Walford who was in the in that
project out in the desert in Arizona was right if we decrease our overall caloric
intake we will decrease our aging process his student Dr. Valter Longo has
done some things to to help make an easy button for for fasting and decreasing
that caloric intake is called fasting mimicking diet or Prolon so Gaby thank
you for attending and thank you for making us aware that we we had another
technical problem Loretta Dillon-Ham good morning I’ve been check
in but couldn’t find you and now I have happy to be here Dr. B thank you very
much for joining us Loretta and I am going to see if I can
move this slide deck back over we had a problem with shares here great now Loretta Dillon-Ham this is a very
interesting topic to me I’m interested in signaling molecules well it’s a very
interesting topic to me as well I am not okay John Deters greetings from
Portland good to talk good to hear from you John
I again we had another technical problem this time had to do with restarting the
program and coming in silent for a few minutes I did repeat it we got most of
that out there if anybody has questions if you go ahead and and plop them up
there I would appreciate it meanwhile I’ll go ahead and let you know
a couple of things that are going on with the with our services if I can get
that presentation up there again I had all these up and ready and
when we had that problem let me just tell you let me just give you verbally
some of the things that are going on there you know the membership website is
is going well we’re improving our abilities to provide services there
we’re providing more and more free services on that membership website if
you haven’t been been there it’s easy to get there I’ll show you real quick how
to get there go to read that then go to membership log in and it will ask you if
you haven’t signed up already I ask you to sign up for a free membership now one of
the things that I wanted to cover tonight was the webinars folks don’t
understand the webinars and it’s our fault we don’t have a lot of advertising
out there yet let me compare webinars to the pricing on our services so our least
expensive service is like 990 and I realize that’s expensive that’s why
we’ve worked on trying to provide courses free videos etc but even with
that 990 it’s a half an hour to an hour with me it doesn’t include labs the
reason I brought that up is that the webinars includes the labs in fact is
I’ve had discussions with folks that are interested in these processes we’ve had
oh we’ve had the reactions like I had no idea
so the webinar price and again I think we still have a few slots for the 199 or
$299 Michelle will let you know that includes the labs themselves so here’s
how this process came to be a lot of people were
watching the videos on how to get the labs on the inflammation panel and the
insulin resistance labs we get some feedback that Quest was no longer
offering direct to patient or patient directed inflammation panels so we said hey you
know we can offer that and now we do the typical price was about 200 to 300
for the inflammation panel and then for patients I don’t really know how much it
was for the for the OGTT I believe it was between 50 and 150 and then another
50 to 150 for the insulin surveys associated with that you get all three
of those right now for I think it’s $299
and after the slots fill up it’ll go up to like 490 so again the webinars
themselves are basically free the value is in the costs the webinars will be an
opportunity for patients to share their on their own lab values and get some
discussion and explanation of what their lab values are describing what they’re
looking like okay we’ve got a new some new questions Daniel Christopher
greetings from London Gaby Hernandez questions related to
today’s subject or any questions related to cardiovascular health any questions
the Wednesday night video Gaby thank you for asking the YouTube live
event is for any questions associated with cardiovascular health and
prevention Loretta Dillon-Ham Dr. B would you explain what
carboxylation sorry about is well Loretta carboxylation is you’re asking
about where that’s a big issue is vitamin K2 there’s a few enzymes like
now I’m going to have senior moments because I’ve gotten so frustrated with
this thing technology again I can’t remember the to
it enzymes they’re a couple of enzymes they’re very important to to vitamin K2
one helps to add calcium to the bone another takes calcium away from the bone
neither one of those enzymes work and let work very well unless they’re
carboxylated so vitamin K2 is involved in carboxylating those enzymes
what does carboxylation again it’s just as it’s a medical technical term a
carboxyl group is a carbon with two oxygens attached to it and all it’s
doing is adding excuse me that carboxyl group to those two enzymes once
it does it changes the the enzymes are proteins and it changes the
configuration of the protein so it can now start working and removing calcium
from an artery wall for example or other tissue and deposit that calcium in a bone area now sometime after I calm down I’m going to remember which show
which two enzymes that I was talking about on K2 if you have curiosity you
can go back and look at the K2 series we just did they’ve been they’ve been
publishing over the past couple of weeks John Deters Dr. B after three months on
low-dose Crestor I had a good result lowering cholesterol and LDL by a
hundred points wow congratulations that’s exciting my high sensitivity CRP
went up from 1 to 2.3 concern I’m rarely concerned about CRP
folks that that do know about inflammation most of them and that’s not
a lot of folks most of them mostly focus on CRP CRP is a C-reactive protein it’s
a protein made by the liver and it’s got way too many false positives um we could
get a hundred people a flu vaccine today two
days from now 60 of them would have a positive CRP so what do we do we look at
a panel of tests one is involving myeloperoxidase another one is Lp-PLA2 those
are both enzymes released by your own immune system as your immune system
attacks and liquefies that plaque the most important inflammatory test is
microalbumin creatinine ratio here’s what that is that’s looking at the
amount of protein that you’re spilling through your kidneys you see each kidney
is about a million filters and a filter is the membrane where you’re pushing
fluid through the fluid the the membrane in this case is the intima that critical
lining of your artery wall the fluid is your blood and the plasma going through
it the most common thing that the marker
that we’re looking at is albumin so microalbumin creatinine ratio the
creatinine just tells us it helps us so adjust the numbers that we see in the
the amount of albumin for that for the level of dehydration here’s the thing if
you get a microalbumin creatinine ratio of 30 or greater it indicates full-blown
kidney disease and that’s usually all the lab will tell you but we know in
terms of cardiovascular inflammation that when you get a level over six to eight if you’re a man or 16 if you’re a woman you probably have inflammation
you have dysfunction of that intima layer what’s the most common cause of
that cigarette smoking can cause it inflammatory diseases like rheumatoid
arthritis but by far the most common causes insulin resistance when the
glycocalyx is made up most it’s the hairy inner lining of the of the intima and glyco means slickers
so it’s made up mostly of glucose with some protein in it and it gets damaged
after just a few hours of blood sugar over 140 180 to 200 so those of us who walk
around with a blood sugar of 180 for hours or just it’s like if you look at
photomicrographs there’s like taking a lawn mower to grass it wipes out huge
portions of that glycocalyx by the way John why don’t you get the the
inflammation course less than two hours now less than thirty bucks you can
figure the whole thing out understand why I’m not quite so worried about CRP
but I’d be more worried about those other those other tests RobTO7 good
evening Doc what was that slide that popped up and said hmmm nicotinamide riboside and I missed the rest of it I have I’m working on a series of decks for the
upcoming Louisville Louisville event and that one
is on supplementation so and it talks about different types of supplement as
you know NAD+ is part of the Krebs cycle part of part of oxidative
phosphorylation don’t worry about that that’s what that is is what the
mitochondria do niacin is creme is the N in nad it’s also niacin or niacinamide
is part of NAD is part of NMN which is David Sinclair’s
most recent supplement for anti-aging again there’s continued research around
niacin NMN on nicotinamide riboside NAD+ so hope that helps answer
the question and again we’ll be covering that
I’ve got videos on it you can take a look therefore they’re free and we’ll be
covering that some at the upcoming event Loretta Dillon-Ham thank you yes I did
watch it okay so Gaby Hernandez what does it mean to have high levels of 11dh TxB2 creatinine I don’t know it’s not a that’s not a space where I’ve been
in Gaby or at least it’s not ringing any bells for me
Loretta Dillon-Ham osteoblast and osteoclasts actually thank you for the
reminder the name of one of those those enzymes that I was thinking about
earlier on K2 is osteocalcin that’s I think that is the one that actually adds
calcium back into the bone those the function of those enzymes by the way is very much or dysfunction is very much
related to insulin resistance so RobTO7 thanks I’m supplementing with NR nicotinamide riboside I hope it keep us posted on that I hope it works well
for you I did that for a while I’m back to plain old niacin right now I have
done some NR I’ve done some NMN and this week after reading LIFESPAN
by David Sinclair I went back to NMN so guys thank you very much for your
your interest and attention if anybody has anything else please go ahead and
pop that question out now I have again had another frustrating evening with
technology we got everything up and rolling we practiced it Michelle and
Cliede did good work getting ready for it I had to come in and go back go back out
come in again on the second time I came in I didn’t realize that I had
gone off of you so again thank you for your your patience okay Daniel
Christopher why does insulin resistance go down with weight loss that’s a really
good question if you’ve seen my video or other videos on the secret life of fat
cells you’ll realize that fat cells in and out of themselves are not just
places for storage of fat fat cells are their endocrine areas they release adiponectin leptin they’re very much a hormonal organ and so it’s not so much
just losing weight that improves insulin resistance it’s losing fat and
specifically those fat cells that are releasing the inflammatory are adipokines Gaby Hernandez is the 11dh TxB2 is under platelet function in the
Cleveland Heartlab again Gaby it’s it’s not something that I have focused
on John Deters thank you very much okay and thank you guys again for your
patience tonight and your interest I am going to sign off


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