FDA-Approved Drug Restores Hair in Patients with Alopecia Areata

FDA-Approved Drug Restores Hair in Patients with Alopecia Areata

alopecia areata is an autoimmune form of
hair loss where T cells attack the growing hair follicle. It is not a
life-threatening form of autoimmunity however it is a life altering form of
autoimmune disease it affects patients in a very profound
and very personal way to undergo hair loss. I could say that with authority
because I’m one of them so the reason my lab studies this is because I actually
have alopecia areata and that’s what really sparked us to do this type of
work over 6 million people in the u.s. also suffer from various forms of
alopecia areata so this is a tremendously large and motivated
population of patients who have no other treatments available treatment for this
disease in the past has been hit and miss with steroids and with varying degrees
of success we’ve been excited to see data both in
mice and now in people to show that we can reverse this disease with small
molecules that are aimed at reversing the inflammatory condition in humans the the trail for ruxolitinib in the treatment of alopecia areata got started based on the
clinical– a genetic and immunologic discoveries made by doctors Christiano
and Klein’s in investigating the genetics of
alopecia areata they were able to then subsequently pinpoint to several immune
pathways that appear to be important in alopecia areata. the next step was
identifying available drugs that actually inhibit these pathways and this
is the basis upon which ruxolitinib was selected. once the drug was selected we
then went about designing a trial to preliminarily test its effect on alopecia
areata we now have the ability to identify potential targets for treatment and using what some people call a “mechanism driven approach,” that is to
look for pathways that are altered in human disease and then to see if those
alterations lend themselves to some type of manipulation either pharmacologically
or genetically or both and I think that’s what
we have in the case of this study which is an autoimmune disease that has eluded for decades any basic understanding of the development and the causation of the
disease we went on to show which immune pathways might be important in the cell
death of the hair follicle and then using those insights we blocked those
pathways in the mouse models showed they were efficacious and then went on to go
on to try medically relevant antibodies and small molecules to see whether when
we block these pathways we could reverse the alopecia areata and we showed that
it was true in mouse models and then went on to go to a small series of
patients and show that the therapies could also be effective in people we are very committed to making sure that that patients with alopecia areata have
access to this class of drugs hopefully in a way someday that’s not an
off-label indication meaning we’d like to pursue getting a label getting an
indication for a jak inhibitor in alopecia areata we’re deeply committed
to doing that there are so many other diseases if you will ahead of us other
diseases that might be considered much more life-threatening or life-altering
that alopecia can sometimes get pushed to the backburner or to the bottom of
the list but this has been the major focus of our entire group and we would
like very much to make sure that this ball gets across the finish line
whatever that takes and hopefully we’ll be joining with some pharmaceutical
partners to make sure that alopecia stays top of mind and that someday this
is an approved indication for jak inhibitor

10 thoughts on “FDA-Approved Drug Restores Hair in Patients with Alopecia Areata

  1. Trouble is how long now before it is available? 10+ years?? And how much is ruxolitinib? I read it cost 1000's of bucks

  2. I  have had spots of alopecia for 2 years now and i have tried everything nothing worked until now ı am not sure which one is working the  *superhairfood alopecia shampoo  or  superhairfood lotion!!* Because I am using both but on monday the 7th ı noticed peach fuss on all of the alopecia spots; ı was surprised and will continue to use both products.

  3. Ok, maybe I missed this, but just because it's FDA approved doesn't mean it's FDA approved for Alopecia. Take Xeljanz for example. it totally treats Alopecia. And it's FDA approved, but for Rheumatoid arthritis. Not for Alopecia.

    I've had Alopecia Universalis for almost 12 years. So I have head to toe hair loss. I'm tired of it. And I'm tired of misleading videos. Although these people clearly have their hearts in the right place, the title suggests they are much closer.

  4. I don't understand why they can treat this woman in the pictures and not everyone else, what is OFF-LABEL INDICATIONS ? and why presume anyone is even expected to understand the definition? What if everyone wants the treatment NOW? Including Angela Christiano!? I just don't understand the delay and the 'back burner'.. Who or What is the obstacle?!

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