Discovery of a New Celiac Disease Risk Factor

Discovery of a New Celiac Disease Risk Factor


A New Risk Factor for Celiac Disease Celiac disease is believed to have a genetic
underpinning So not everyone gets celiac disease Patients have risk genes, found in 40% of
the population But it turns out that only 1% of people actually
develop celiac disease So you take thousands of patients and thousands
of normal individuals and you sequence their genomes What kind of changes in the genome sequence more likely shows up in the patients than
in the normal individuals? What you find is that some of those changes
are located within protein-coding regions And people always studied them because they’re
easier to study But the vast majority of changes that are
found are in noncoding regions And researchers have ignored those regions
because they are harder to study These are RNA molecules that do not produce
protein We’ve found this long non-coding RNA that
appears to represent an important risk gene that contributes to
the development of celiac disease


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