10 Bizarre Diseases With No Cure


10 Bizarre Diseases With No Cure 10) Benjamin Button Syndrome Progeria is an extremely rare genetic disorder
that causes those with the disease to age ten times faster than normal. Although those with progeria have above average
intelligence, the syndrome affects their physical bodies, causing them to look older than their
years. Symptoms include stunted growth, hair loss, pinched facial features, and fragile
bodies. The disease is caused by a mutation during
embryonic development, which has led scientists studying it to gain a better understanding
of the aging process. People with progeria have a life expectancy
of 13 years, and it is thought to affect approximately 1 in 8 million births. Source: BBC, CNN 9) Persistent Genital Arousal Disorder Persistent Genital Arousal Disorder (PGAD)
is an incurable disease, which causes its female sufferers to experience painful, consistent
sexual arousal. Those that suffer from the illness feel that
they are on the verge of an orgasm they can’t complete – for days or weeks at a time. Other
sufferers experience uncontrollable multiple orgasms. One sufferer, Cara Anaya, reported that her
illness could make her experience up to 180 orgasms in just two hours. The symptoms can be triggered by anything
from a bumpy bus ride to the vibration of a cell phone. Source: Guardian, Huffington Post 8) Werewolf Syndrome Hypertrichosis [high-per-trik-oh-sis], also
known as Werewolf Syndrome, is an extremely rare genetic condition, which causes an abnormal
amount of hair to grow across the face and body. The genetic disease is so rare that since
the Middle Ages only 50 individuals with the disease have been recorded. However, despite
few cases to study, researchers have been able to identify that the excessive hairiness
is due to a mutation to a section of the X chromosome. In the 19th and 20th century sufferers of
Hypertrichosis often worked as sideshow freaks, such as Mexican dancer Julia Pastrana. She
was exhibited at circuses around the world as a human-ape hybrid and was later stuffed
and displayed as a specimen after death. Advances in hair removal techniques means
families with Hypertrichosis can achieve temporary relief from their hairy symptoms. Source: Medscape, Guardian 7) Fish Odor Syndrome This fishy syndrome is a rare metabolic disorder
that prevents the body from breaking down the compound trimethylamine [try-meth-al-zam
theen]. Trimethylamine is found in foods such as red
meat and eggs, and those who ingest it can suffer from a build up of the chemical, which
is released as a stench of rotten fish through their sweat, urine, and breath. The incurable condition is thought to be more
common in women than men. Scientists attribute this to female sex hormones such as estrogen,
which are though to heighten the symptoms. Sources: NCBI 6) Vampire Syndrome HED is a rare genetic disorder that can leave
those that inherit it resembling a vampire. The disorder causes an absence of sweat glands
and thin skin that lacks pigmentation. This means that sufferers have to avoid direct
sunlight to prevent heat blisters or overheating, which can occur within minutes of exposure. The disorder also affects the growth of hair
and teeth, leaving those with the disease to appear as if they have fangs, while other
affected individuals lack teeth altogether. Sources: Rarediseases.org 5) Water Allergy Aquagenic urticaria [Aqua g nic] [ur tick
care ria] is a disease that leaves people experiencing agonizing hives if they come
into contact with water – including their own sweat or tears. Despite human bodies being made up of 70%
water, some sufferers of aquagenic urticaria can’t even drink the stuff, as the contact
with water causes their throat to close up. Showers have to be limited to a few minutes
a week, otherwise sufferers run the risk of being sent into severe anaphylactic [anna-fa-lack-tick]
shock. Scientists don’t know what causes the disease
and are yet to develop a cure, as it is so rare that it only affects 1 in 230 million
people. That’s approximately 40 people worldwide. Sources: ABC News, NCBI 4) Hailey-Hailey Disease Hailey-Hailey disease is an inherited skin
condition that causes red, itchy scales and blisters to appear when the skin is irritated. The disease can flare up due to the slightest
friction. Everyday activities such as walking can lead to severe pain in the groin, genital
area, or in the crease of the buttocks. Extreme instances can result in infection,
discharge, and a rotting smell. The symptoms of Hailey-Hailey disease are
caused by weakened cells on the surface layer of the skin. Although there is no cure, antibiotic
creams and antiseptic soap can help manage the symptoms. Source: British Association of Dermatologists 3) Tree Man The Tree Man illness is named after the tree-like
warts that grow on sufferers of the disease. One sufferer, Dede Koswara [Day Day] [Co saw
ra], caught the disease after cutting his knee in an accident. The warts are caused by the common infection
HPV, but Koswara’s genetically low immune system meant that the virus hijacked the cellular
machinery of his skin cells, resulting in the uncontrollable growths. Despite undergoing treatment, which removed
95% of the tree-like growths, they grew back just a few months later, covering his hands
and feet and leaving him unable to carry out basic tasks. Source: The Telegraph 2) Sellars’ Syndrome British woman Mandy Sellars made headlines
while attempting to raise awareness for her unique disease, which has left her with abnormally
oversized legs. Caused by a faulty gene, the syndrome has
caused her legs to grow uncontrollably. They now weigh more than 107 kg, despite the top
half of her body growing at a normal rate. Her overgrown limbs have caused Sellars further
health complications, including a spinal stroke and blood infection. This led to her left
leg being amputated, but even despite the amputation the stump continued to grow at
an accelerated rate. After genetic testing it was revealed that
Sellars’ case is the first of its kind, a 1 in 7 billion disease. Source: BBC, Mandy Sellars 1) Stone Man Syndrome FOP disease, also known as Stone Man Syndrome,
is a genetic disorder that turns soft tissue into bone, transforming sufferers into a living
statue. The disease is caused by mutations to the
gene ACVR1, which is responsible for turning cartilage into bone as children develop. For
those with FOP the gene is pushed into overdrive, fusing their bones together, resulting in
frozen limbs and a locked the jaw. This makes eating and breathing independently nearly
impossible. There is currently no cure for the disease
and attempts to surgically remove the excess bone results in an explosion in bone growth. This lethal genetic disorder is one of the
world’s rarest known diseases, affecting just 1 in 2 million people. Sources: CBS News, IFL Science, Huffington
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